| St.Mary's, CA Games/Schedule |
| Regular Season |
| Nov. 9, 2021 | Day 1 | PVAMU - St.Mary's, CA (14) | 68-87  |
| Nov. 12, 2021 | Day 4 | Texas Southern - St.Mary's, CA (14) | 58-67 |
| Nov. 15, 2021 | Day 7 | SUU - St.Mary's, CA (14) | 51-70 |
| Nov. 17, 2021 | Day 9 | Bellarmine - St.Mary's, CA (14) | 64-73 |
| Nov. 22, 2021 | Day 14 | St.Mary's, CA (14) - Notre Dame | 62-59 |
| Nov. 23, 2021 | Day 15 | Oregon - St.Mary's, CA (14) | 50-62 |
| Nov. 24, 2021 | Day 16 | Wisconsin - St.Mary's, CA (14) | 61-55  |
| Nov. 29, 2021 | Day 21 | UC Riverside - St.Mary's, CA (14) | 50-67 |
| Dec. 2, 2021 | Day 24 | St.Mary's, CA (14) - Utah St. | 60-58 |
| Dec. 4, 2021 | Day 26 | St.Mary's, CA (14) - Colorado St. (20) | 58-74 |
| Dec. 11, 2021 | Day 33 | UCSB - St.Mary's, CA (14) | 59-80 |
| Dec. 14, 2021 | Day 36 | CS Stanislaus - St.Mary's, CA (14) | 39-76 |
| Dec. 17, 2021 | Day 39 | SDSU - St.Mary's, CA (14) | 63-53 |
| Dec. 22, 2021 | Day 44 | Missouri St. - St.Mary's, CA (14) | 58-75 |
| Dec. 28, 2021 | Day 46 | Yale - St.Mary's, CA (14) | 60-87 |
| Jan. 8, 2022 | Day 57 | St.Mary's, CA (14) - BYU | 43-52 |
| Jan. 13, 2022 | Day 62 | St.Mary's, CA (14) - Pepperdine | 77-62 |
| Jan. 20, 2022 | Day 69 | Santa Clara - St.Mary's, CA (14) | 65-73 |
| Jan. 22, 2022 | Day 71 | St.Mary's, CA (14) - LMU | 83-51 |
| Jan. 27, 2022 | Day 76 | St.Mary's, CA (14) - USF | 72-70 |
| Jan. 29, 2022 | Day 78 | Pepperdine - St.Mary's, CA (14) | 57-81 |
| Feb. 3, 2022 | Day 83 | St.Mary's, CA (14) - Portland | 75-54 |
| Feb. 5, 2022 | Day 85 | LMU - St.Mary's, CA (14) | 60-71 |
| Feb. 8, 2022 | Day 88 | St.Mary's, CA (14) - Santa Clara | 72-77 |
| Feb. 10, 2022 | Day 90 | San Diego - St.Mary's, CA (14) | 57-86 |
| Feb. 12, 2022 | Day 92 | St.Mary's, CA (14) - Gonzaga (1) | 58-74 |
| Feb. 17, 2022 | Day 97 | USF - St.Mary's, CA (14) | 64-69 |
| Feb. 19, 2022 | Day 99 | BYU - St.Mary's, CA (14) | 64-69 |
| Feb. 24, 2022 | Day 104 | St.Mary's, CA (14) - San Diego | 60-46 |
| Feb. 26, 2022 | Day 106 | Gonzaga (1) - St.Mary's, CA (14) | 57-67 |
| Mar. 7, 2022 | Day 115 | Santa Clara - St.Mary's, CA (14) | 72-75 |
| Mar. 8, 2022 | Day 116 | St.Mary's, CA (14) - Gonzaga (1) | 69-82 |
| National Tournament Day 1 |
| Mar. 17, 2022 | Day 122 | Indiana - St.Mary's, CA (14) | 53-82 |
| National Tournament Day 2 |
| Mar. 19, 2022 | Day 123 | St.Mary''s, CA (14) - UCLA (11) | 56-72 |
